Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4.

ABSTRACT: Neuronal gene expression is modulated by activity via calcium-permeable receptors such as NMDA receptors (NMDARs). While gene expression changes downstream of evoked NMDAR activity have been well studied, much less is known about gene expression changes that occur under conditions of basal neuronal activity. In mouse dissociated hippocampal neuronal cultures, we found that a broad NMDAR antagonist, AP5, induced robust gene expression changes under basal activity, but subtype-specific antagonists did not. While some of the gene expression changes are also known to be downstream of stimulated NMDAR activity, others appear specific to basal NMDAR activity. The genes altered by AP5 treatment of basal cultures were enriched for pathways related to class IIa histone deacetylases (HDACs), apoptos

SUBMITTER: Chen Y 

PROVIDER: S-EPMC4228135 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature