MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1.

ABSTRACT:

Background

Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to human disease including carcinogenesis and tumor metastasis in human. miR-124-3p is down-regulated in various cancers, and modulates proliferation and aggressiveness of cancer cells. However, the roles of miR-124-3p in human bladder cancer are elusive. Thus, this study was conducted to investigate the biological functions and its molecular mechanisms of miR-124-3p in human bladder cancer cell lines, discussing whether it has a potential to be a therapeutic biomarker of bladder cancer.

Methods

Three human bladder cancer cell lines and samples from ten patients with bladder cancer were analyzed for the expression of miR-124-3p by quantitative RT--PCR. Exogenetic over

SUBMITTER: Xu X 

PROVIDER: S-EPMC4228407 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature