Common low-penetrance risk variants associated with breast cancer in Polish women.

ABSTRACT:

Background

Breast cancer is the most common type of cancer and the second leading cause of cancer-death among women in Poland. The known high-risk mutations account for 25% of familial aggregation cases and 5% of total breast cancer predisposition. Genome-wide association studies have identified a number of common low-penetrance genetic variants, but their contribution to disease risk differs between populations.

Methods

To verify selected associations with breast cancer susceptibility among Polish women, the replication study was performed, included 1424 women with breast cancer and 1788 healthy persons. Sixteen single-nucleotide polymorphisms (SNPs) were analyzed using TaqMan SNP Genotyping Assays. Allele frequency differences were tested using chi2-test implemented in PLI

SUBMITTER: Ledwon JK 

PROVIDER: S-EPMC4228440 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature