Revisiting robustness and evolvability: evolution in weighted genotype spaces.

ABSTRACT: Robustness and evolvability are highly intertwined properties of biological systems. The relationship between these properties determines how biological systems are able to withstand mutations and show variation in response to them. Computational studies have explored the relationship between these two properties using neutral networks of RNA sequences (genotype) and their secondary structures (phenotype) as a model system. However, these studies have assumed every mutation to a sequence to be equally likely; the differences in the likelihood of the occurrence of various mutations, and the consequence of probabilistic nature of the mutations in such a system have previously been ignored. Associating probabilities to mutations essentially results in the weighting of genotype space. We here

SUBMITTER: Partha R 

PROVIDER: S-EPMC4229248 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature