Statins, mood, sleep, and physical function: a systematic review.

ABSTRACT:

Purpose

We aimed to evaluate the effects of statins on mood, sleep, and physical function.

Methods

We performed a systematic computer-aided search of MEDLINE/PubMed, EMBASE, and the Cochrane Central Register and augmented this search by scrutinizing reference lists and making inquiries among colleagues and experts in the field. All patient populations and study types were considered. We selected studies of statin therapy compared with no statin or placebo. Outcome measures included mood, sleep, and physical function.

Results

Thirty-four studies were included in qualitative synthesis. Seven of eight (88 %) observational studies, 4/6 (66 %) randomized trials with mood as a primary endpoint (487 total participants; exposure 4 weeks to 1 year), and 3/3 (100 %) randomized

SUBMITTER: Swiger KJ 

PROVIDER: S-EPMC4229431 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature