Changes in cellular immune activation and memory T-cell subsets in HIV-infected Zambian children receiving HAART.

ABSTRACT:

Background

Increased exposure to a broad array of pathogens in children residing in sub-Saharan Africa may lead to heightened immune activation and increased proportions of memory T cells. Changes in the size of these cellular subsets have implications for restoration of normal immune function after treatment with highly active antiretroviral therapy (HAART) and are not well characterized in young sub-Saharan African children.

Methods

CD4⁺ and CD8⁺ T-cell subsets were measured by flow cytometry in 157 HIV-infected Zambian children before and at 3-month intervals during HAART for up to 30 months and in 34 control children at a single study visit.

Results

Before HAART, HIV-infected children had higher levels of activated and effector memory (EM) CD4⁺ and CD8⁺ T cells, a

SUBMITTER: Rainwater-Lovett K 

PROVIDER: S-EPMC4229446 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature