Patterns and correlates of PrEP drug detection among MSM and transgender women in the Global iPrEx Study.

ABSTRACT:

Background

Adherence to pre-exposure prophylaxis (PrEP) is critical for efficacy. Antiretroviral concentrations are an objective measure of PrEP use and correlate with efficacy. Understanding patterns and correlates of drug detection can identify populations at risk for nonadherence and inform design of PrEP adherence interventions.

Methods

Blood antiretroviral concentrations were assessed among active arm participants in iPrEx, a randomized placebo-controlled trial of emtricitabine/tenofovir in men who have sex with men and transgender women in 6 countries. We evaluated rates and correlates of drug detection among a random sample of 470 participants at week 8 and a longitudinal cohort of 303 participants through 72 weeks of follow-up.

Results

Overall, 55% of particip

SUBMITTER: Liu A 

PROVIDER: S-EPMC4229454 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature