IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis.

ABSTRACT:

Background

Psoriatic arthritis (PsA) is a chronic inflammatory disease characterised by clinical features that include bone loss and epidermal hyperplasia. Aberrant cytokine expression has been linked to joint and skin pathology; however, it is unclear which cytokines are critical for disease initiation. Interleukin 17A (IL-17A) participates in many pathological immune responses; however, its role in PsA has not been fully elucidated.

Objective

To determine the role of IL-17A in epidermal hyperplasia and bone destruction associated with psoriatic arthritis.

Design

An in vivo gene transfer approach was used to investigate the role of IL-17A in animal models of inflammatory (collagen-induced arthritis) and non-inflammatory (receptor activator of NF-κB ligand (RANKL)-gen

SUBMITTER: Adamopoulos IE 

PROVIDER: S-EPMC4229480 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature