Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder.

ABSTRACT: Individuals with bipolar disorder (BD) exhibit deleterious decision making, negatively impacting their lives. Such aberrant decision making can be quantified using the Iowa Gambling Task (IGT), which requires choosing between advantageous and disadvantageous options based on different reward/punishment schedules. The mechanisms underlying this behavioral deficit are unknown, but may include the reduced dopamine transporter (DAT) functioning reported in BD patients. Using both human and mouse IGTs, we tested whether reduced DAT functioning would recreate patterns of deficient decision making of BD patients. We assessed the IGT performance of 16 BD subjects (7 female) and 17 healthy control (HC) subjects (12 female). We recorded standard IGT performance measures and novel post-reward and pos

SUBMITTER: van Enkhuizen J 

PROVIDER: S-EPMC4229584 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature