Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols.

ABSTRACT: We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol-oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT-OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT-OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.

SUBMITTER: Murray J 

PROVIDER: S-EPMC4229624 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature