Serpin peptidase inhibitor clade A member 1 is a biomarker of poor prognosis in gastric cancer.

ABSTRACT:

Background

In a previous study, we reported that serpin peptidase inhibitor clade A member 1 (serpinA1) is upregulated in Snail-overexpressing gastric cancer. Although serpinA1 has been studied in several types of cancer, little is known about its roles and mechanisms of action. In this study, we examined the role of serpinA1 in the migration and invasion of gastric cancers and determined its underlying mechanism.

Methods

Expression levels were assessed by western blot analyses and real-time PCR. Snail binding to serpinA1 promoter was analysed by chromatin immunoprecipitation (ChIP) assays. The roles of serpinA1 were studied using cell invasion and migration assays. In addition, the clinicopathologic and prognostic significance of serpinA1 expression were validated in 400 ga

SUBMITTER: Kwon CH 

PROVIDER: S-EPMC4229634 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature