Relationships between pazopanib exposure and clinical safety and efficacy in patients with advanced renal cell carcinoma.

ABSTRACT:

Background

Pazopanib, an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit, is approved in locally advanced/metastatic renal cell carcinoma (RCC).

Methods

Data from trials in advanced solid tumours and advanced/metastatic RCC were used to explore the relationships between plasma pazopanib concentrations and biomarker changes, safety, and efficacy. Initially, the relationships between pharmacokinetic parameters and increased blood pressure were investigated, followed by analysis of steady-state trough concentration (Cτ) and sVEGFR2, safety, progression-free survival (PFS), response rate, and tumour shrinkage. Efficacy/safety end points were compared at Cτ decile boundaries.

Result

SUBMITTER: Suttle AB 

PROVIDER: S-EPMC4229638 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature