Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection.

ABSTRACT:

Introduction

Inherited variability in host immune responses influences susceptibility and outcome of Influenza A virus (IAV) infection, but these factors remain largely unknown. Components of the innate immune response may be crucial in the first days of the infection. The collectins surfactant protein (SP)-A1, -A2, and -D and mannose-binding lectin (MBL) neutralize IAV infectivity, although only SP-A2 can establish an efficient neutralization of poorly glycosylated pandemic IAV strains.

Methods

We studied the role of polymorphic variants at the genes of MBL (MBL2), SP-A1 (SFTPA1), SP-A2 (SFTPA2), and SP-D (SFTPD) in 93 patients with H1N1 pandemic 2009 (H1N1pdm) infection.

Results

Multivariate analysis showed that two frequent SFTPA2 missense alleles (rs1965708-C and

SUBMITTER: Herrera-Ramos E 

PROVIDER: S-EPMC4229788 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature