Improvement of bone regeneration capability of ceramic scaffolds by accelerated release of their calcium ions.

ABSTRACT: To regenerate the bone tissue, the fabrication of scaffolds for better tissue regeneration has attracted a great deal of attention. In fact, growth factors are already used in clinical practice and are being investigated for enhancing the capacity for bone tissue regeneration. However, despite their strong osteoinductive activity, these growth factors have several limitations: safety issues, high treatment costs, and the potential for ectopic bone formation. The aim of this study was therefore to develop ceramic scaffolds that could promote the capacity for bone regeneration without growth factors. Three-dimensional ceramic scaffolds were successfully fabricated from hydroxyapatite (HA) and tricalcium phosphate (TCP) using projection-based microstereolithography, which is an additive manuf

SUBMITTER: Seol YJ 

PROVIDER: S-EPMC4229868 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature