Dataset Information

A 41-gene signature derived from breast cancer stem cells as a predictor of survival.

ABSTRACT:

Purpose

The aim of this study was to evaluate the ability of a 41-gene signature derived from breast cancer stem cells (BCSCs) to estimate the risk of metastasis and survival in breast cancer patients.

Methods

The centroid expression of the 41-gene signature derived from BCSCs was applied as the threshold to classify patients into two separate groups--patients with high expression (high-EL) of the prognostic signature and patients with low expression (low-EL). The predictive ability of the 41-gene signature was evaluated by Cox regression model and was compared against other popular tests, such as Oncotype and MammaPrint.

Results

Our results showed that the 41-gene prognostic signature was significantly associated with age (P = .0351) and ER status (P = .0095). The analysis indicated that patients in the high-EL group had a worse prognosis than those in the low-EL group in terms of both overall survival (OS: HR, 2.05, P = .009) and distant metastasis-free survival (DMFS: HR, 2.24, P = .002). Additionally, the 41-gene signature was an independent risk factor and separates patients based on estrogen receptor status. While comparable to Oncotype, the analysis demonstrated that the 41-gene signature had a better prognostic value in predicting DMFS and OS than AOL, NPI, St. Gallen, Veridex, and MammaPrint.

Conclusions

This study confirms the utility of the 41-gene signature and adds to the growing evidence that gene expression signatures of BCSCs have clinical potential to predict patient outcome and aid in treatment choice.

SUBMITTER: Yin ZQ

PROVIDER: S-EPMC4229870 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Publications

A 41-gene signature derived from breast cancer stem cells as a predictor of survival.

Yin Zhi-Qiang ZQ Liu Jian-Jun JJ Xu Ying-Chun YC Yu Jian J Ding Guo-Hui GH Yang Feng F Tang Lei L Liu Bao-Hong BH Ma Yue Y Xia Yu-Wei YW Lin Xiao-Lin XL Wang Hong-Xia HX

Journal of experimental & clinical cancer research : CR 20140606

<h4>Purpose</h4>The aim of this study was to evaluate the ability of a 41-gene signature derived from breast cancer stem cells (BCSCs) to estimate the risk of metastasis and survival in breast cancer patients.<h4>Methods</h4>The centroid expression of the 41-gene signature derived from BCSCs was applied as the threshold to classify patients into two separate groups--patients with high expression (high-EL) of the prognostic signature and patients with low expression (low-EL). The predictive abili ...[more]

PMID: 24906694

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Dataset Information

A 41-gene signature derived from breast cancer stem cells as a predictor of survival.

Purpose

Methods

Results

Conclusions

Publications

A 41-gene signature derived from breast cancer stem cells as a predictor of survival.

Similar Datasets

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