A 41-gene signature derived from breast cancer stem cells as a predictor of survival.

ABSTRACT:

Purpose

The aim of this study was to evaluate the ability of a 41-gene signature derived from breast cancer stem cells (BCSCs) to estimate the risk of metastasis and survival in breast cancer patients.

Methods

The centroid expression of the 41-gene signature derived from BCSCs was applied as the threshold to classify patients into two separate groups--patients with high expression (high-EL) of the prognostic signature and patients with low expression (low-EL). The predictive ability of the 41-gene signature was evaluated by Cox regression model and was compared against other popular tests, such as Oncotype and MammaPrint.

Results

Our results showed that the 41-gene prognostic signature was significantly associated with age (P = .0351) and ER status (P = .0095). The an

SUBMITTER: Yin ZQ 

PROVIDER: S-EPMC4229870 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature