EPIQ-efficient detection of SNP-SNP epistatic interactions for quantitative traits.

ABSTRACT:

Motivation

Gene-gene interactions are of potential biological and medical interest, as they can shed light on both the inheritance mechanism of a trait and on the underlying biological mechanisms. Evidence of epistatic interactions has been reported in both humans and other organisms. Unlike single-locus genome-wide association studies (GWAS), which proved efficient in detecting numerous genetic loci related with various traits, interaction-based GWAS have so far produced very few reproducible discoveries. Such studies introduce a great computational and statistical burden by necessitating a large number of hypotheses to be tested including all pairs of single nucleotide polymorphisms (SNPs). Thus, many software tools have been developed for interaction-based case-control studies,

SUBMITTER: Arkin Y 

PROVIDER: S-EPMC4229902 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature