The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells.

ABSTRACT:

Background

Tumor heterogeneity and the plasticity of cancer cells present challenges for effective clinical diagnosis and therapy. Such challenges are epitomized by neuroendocrine transdifferentiation (NED) and the emergence of neuroendocrine-like cancer cells in prostate tumors. This phenomenon frequently arises from androgen-depleted prostate adenocarcinoma and is associated with the development of castration-resistant prostate cancer and poor prognosis.

Results

In this study, we showed that NED was evoked in both androgen receptor (AR)-positive and AR-negative prostate epithelial cell lines by growing the cells to a high density. Androgen depletion and high-density cultivation were both associated with cell cycle arrest and deregulated expression of several cell cycle reg

SUBMITTER: Pernicova Z 

PROVIDER: S-EPMC4229954 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature