Homology-based prediction of interactions between proteins using Averaged One-Dependence Estimators.

ABSTRACT:

Background

Identification of protein-protein interactions (PPIs) is essential for a better understanding of biological processes, pathways and functions. However, experimental identification of the complete set of PPIs in a cell/organism ("an interactome") is still a difficult task. To circumvent limitations of current high-throughput experimental techniques, it is necessary to develop high-performance computational methods for predicting PPIs.

Results

In this article, we propose a new computational method to predict interaction between a given pair of protein sequences using features derived from known homologous PPIs. The proposed method is capable of predicting interaction between two proteins (of unknown structure) using Averaged One-Dependence Estimators (AODE) and thre

SUBMITTER: Murakami Y 

PROVIDER: S-EPMC4229973 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature