Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis.

ABSTRACT:

Background

Wound healing is the first stage of a series of cellular events that are necessary to initiate a regenerative response. Defective wound healing can block regeneration even in animals with a high regenerative capacity. Understanding how signals generated during wound healing promote regeneration of lost structures is highly important, considering that virtually all animals have the ability to heal but many lack the ability to regenerate missing structures. Cnidarians are the phylogenetic sister taxa to bilaterians and are highly regenerative animals. To gain a greater understanding of how early animals generate a regenerative response, we examined the cellular and molecular components involved during wound healing in the anthozoan cnidarian Nematostella vectensis.

Resu

SUBMITTER: DuBuc TQ 

PROVIDER: S-EPMC4229989 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature