Low CA II expression is associated with tumor aggressiveness and poor prognosis in gastric cancer patients.

ABSTRACT:

Background

Carbonic anhydrase II is present in normal gastric mucosa; thus, this study aimed to investigate whether its expression persisted in neoplastic gastric tissues, as well as its prognostic value for gastric cancer patients.

Methods

The protein CA II expression pattern was retrospectively analyzed by immunohistochemistry in 181 gastric cancer patients who had undergone gastrectomy. The relationship between the CA II expression level and clinicopathological parameters was investigated. Survival analysis according to CA II expression was measured by Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of CA II expression.

Results

CA II expression was significantly decreased in gastric cancer tissue

SUBMITTER: Hu X 

PROVIDER: S-EPMC4230095 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature