Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.

ABSTRACT:

Background

Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant women is 30 μg/d, whereas 35 μg/d is recommended for lactating women. However, pregnant and lactating women may require more biotin to meet the demands of these reproductive states.

Objective

The current study sought to quantify the impact of reproductive state on biotin status response to a known dietary intake of biotin.

Methods

To achieve this aim, we measured a panel of biotin biomarkers among pregnant (gestational week 27 at study entry; n = 26), lactating (postnatal week 5 at study entry; n = 28), an

SUBMITTER: Perry CA 

PROVIDER: S-EPMC4230210 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature