Integration of molecular network data reconstructs Gene Ontology.

ABSTRACT:

Motivation

Recently, a shift was made from using Gene Ontology (GO) to evaluate molecular network data to using these data to construct and evaluate GO. Dutkowski et al. provide the first evidence that a large part of GO can be reconstructed solely from topologies of molecular networks. Motivated by this work, we develop a novel data integration framework that integrates multiple types of molecular network data to reconstruct and update GO. We ask how much of GO can be recovered by integrating various molecular interaction data.

Results

We introduce a computational framework for integration of various biological networks using penalized non-negative matrix tri-factorization (PNMTF). It takes all network data in a matrix form and performs simultaneous clustering of genes and

SUBMITTER: Gligorijevic V 

PROVIDER: S-EPMC4230235 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature