Graph analysis of β2 adrenergic receptor structures: a "social network" of GPCR residues.

ABSTRACT:

Purpose

G protein-coupled receptors (GPCRs) are a superfamily of membrane proteins of vast pharmaceutical interest. Here, we describe a graph theory-based analysis of the structure of the β2 adrenergic receptor (β2 AR), a prototypical GPCR. In particular, we illustrate the network of direct and indirect interactions that link each amino acid residue to any other residue of the receptor.

Methods

Networks of interconnected amino acid residues in proteins are analogous to social networks of interconnected people. Hence, they can be studied through the same analysis tools typically employed to analyze social networks - or networks in general - to reveal patterns of connectivity, influential members, and dynamicity. We focused on the analysis of closeness-centrality, which is a m

SUBMITTER: Sheftel S 

PROVIDER: S-EPMC4230308 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature