Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks.

ABSTRACT: Convergent functional genomics (CFG) is a translational methodology that integrates in a Bayesian fashion multiple lines of evidence from studies in human and animal models to get a better understanding of the genetics of a disease or pathological behavior. Here the integration of data sets that derive from forward genetics in animals and genetic association studies including genome wide association studies (GWAS) in humans is described for addictive behavior. The aim of forward genetics in animals and association studies in humans is to identify mutations (e.g. SNPs) that produce a certain phenotype; i.e. "from phenotype to genotype". Most powerful in terms of forward genetics is combined quantitative trait loci (QTL) analysis and gene expression profiling in recombinant inbreed rodent li

SUBMITTER: Spanagel R 

PROVIDER: S-EPMC4230431 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature