Evaluation of glycomic profiling as a diagnostic biomarker for epithelial ovarian cancer.

ABSTRACT:

Background

Prior studies suggested that glycans were differentially expressed in patients with ovarian cancer and controls. We hypothesized that glycan-based biomarkers might serve as a diagnostic test for ovarian cancer and evaluated the ability of glycans to distinguish ovarian cancer cases from matched controls.

Methods

Serum samples were obtained from the tissue-banking repository of the Gynecologic Oncology Group, and included healthy female controls (n = 100), women diagnosed with low malignant potential (LMP) tumors (n = 52), and epithelial ovarian cancers (EOC) cases (n = 147). Cases and controls were matched on age at enrollment within ±5 years. Serum samples were analyzed by glycomics analysis to detect abundance differences in glycan expression levels. A two-stage

SUBMITTER: Kim K 

PROVIDER: S-EPMC4230493 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature