An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3.

ABSTRACT:

Introduction

The aim of the study was to interrogate the genetic architecture and autoimmune pleiotropy of scleroderma susceptibility in the Australian population.

Methods

We genotyped individuals from a well-characterized cohort of Australian scleroderma patients with the Immunochip, a custom array enriched for single nucleotide polymorphisms (SNPs) at immune loci. Controls were taken from the 1958 British Birth Cohort. After data cleaning and adjusting for population stratification the final dataset consisted of 486 cases, 4,458 controls and 146,525 SNPs. Association analyses were conducted using logistic regression in PLINK. A replication study was performed using 833 cases and 1,938 controls.

Results

A total of eight loci with suggestive association (P <10-4.5) we

SUBMITTER: Zochling J 

PROVIDER: S-EPMC4230517 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature