The effects of GLP-1 analogues, DPP-4 inhibitors and SGLT2 inhibitors on the renal system.

ABSTRACT: Diabetic nephropathy (DN) affects an estimated 20%-40% of patients with type 2 diabetes mellitus (T2DM). Key modifiable risk factors for DN are albuminuria, anaemia, dyslipidaemia, hyperglycaemia and hypertension, together with lifestyle factors, such as smoking and obesity. Early detection and treatment of these risk factors can prevent DN or slow its progression, and may even induce remission in some patients. DN is generally preceded by albuminuria, which frequently remains elevated despite treatment in patients with T2DM. Optimal treatment and prevention of DN may require an early, intensive, multifactorial approach, tailored to simultaneously target all modifiable risk factors. Regular monitoring of renal function, including urinary albumin excretion, creatinine clearance and glomerul

SUBMITTER: Schernthaner G 

PROVIDER: S-EPMC4230539 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature