Ontology highlight
ABSTRACT:
SUBMITTER: Lavieu G
PROVIDER: S-EPMC4230591 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20140807 19
In mammalian cells, individual Golgi stacks fuse laterally to form the characteristic perinuclear ribbon structure. Yet the purpose of this remarkable structure has been an enigma. We report that breaking down the ribbon of mammalian cells strongly inhibits intra-Golgi transport of large cargoes without altering the rate of transport of smaller cargoes. In addition, insect cells that naturally harbor dispersed Golgi stacks have limited capacity to transport artificial oversized cargoes. These re ...[more]