Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber.

ABSTRACT: During tissue elongation from stage 9 to stage 10 in Drosophila oogenesis, the egg chamber increases in length by ∼1.7-fold while increasing in volume by eightfold. During these stages, spontaneous oscillations in the contraction of cell basal surfaces develop in a subset of follicle cells. This patterned activity is required for elongation of the egg chamber; however, the mechanisms generating the spatiotemporal pattern have been unclear. Here we use a combination of quantitative modeling and experimental perturbation to show that mechanochemical interactions are sufficient to generate oscillations of myosin contractile activity in the observed spatiotemporal pattern. We propose that follicle cells in the epithelial layer contract against pressure in the expanding egg chamber. As tension

SUBMITTER: Koride S 

PROVIDER: S-EPMC4230628 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature