Comparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats.

ABSTRACT:

Background

The comparability of gene expression between blood and brain tissues is a central issue in neuropsychiatric research where the analysis of molecular mechanisms in the brain is of high importance for the understanding of the diseases and the discovery of biomarkers. However, the accessibility of brain tissue is limited. Therefore, knowledge about how easily accessible peripheral tissue, e. g. blood, is comparable to and reflects gene expression of brain regions will help to advance neuropsychiatric research.

Description

Gene expression in the blood, hippocampus (HC) and prefrontal cortex (PFC) of genetically identical rats was compared using a genome-wide Affymetrix gene expression microarray covering 29,215 expressed genes. A total of 56.8% of 15,717 expressed gen

SUBMITTER: Witt SH 

PROVIDER: S-EPMC4230692 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature