A neural population model incorporating dopaminergic neurotransmission during complex voluntary behaviors.

ABSTRACT: Assessing brain activity during complex voluntary motor behaviors that require the recruitment of multiple neural sites is a field of active research. Our current knowledge is primarily based on human brain imaging studies that have clear limitations in terms of temporal and spatial resolution. We developed a physiologically informed non-linear multi-compartment stochastic neural model to simulate functional brain activity coupled with neurotransmitter release during complex voluntary behavior, such as speech production. Due to its state-dependent modulation of neural firing, dopaminergic neurotransmission plays a key role in the organization of functional brain circuits controlling speech and language and thus has been incorporated in our neural population model. A rigorous mathematical p

SUBMITTER: Furtinger S 

PROVIDER: S-EPMC4230744 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature