Small RNAs from plants, bacteria and fungi within the order Hypocreales are ubiquitous in human plasma.

ABSTRACT:

Background

The human microbiome plays a significant role in maintaining normal physiology. Changes in its composition have been associated with bowel disease, metabolic disorders and atherosclerosis. Sequences of microbial origin have been observed within small RNA sequencing data obtained from blood samples. The aim of this study was to characterise the microbiome from which these sequences are derived.

Results

Abundant non-human small RNA sequences were identified in plasma and plasma exosomal samples. Assembly of these short sequences into longer contigs was the pivotal novel step in ascertaining their origin by BLAST searches. Most reads mapped to rRNA sequences. The taxonomic profiles of the microbes detected were very consistent between individuals but distinct from mi

SUBMITTER: Beatty M 

PROVIDER: S-EPMC4230795 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature