Achieving population-level immunity to rabies in free-roaming dogs in Africa and Asia.

ABSTRACT: Canine rabies can be effectively controlled by vaccination with readily available, high-quality vaccines. These vaccines should provide protection from challenge in healthy dogs, for the claimed period, for duration of immunity, which is often two or three years. It has been suggested that, in free-roaming dog populations where rabies is endemic, vaccine-induced protection may be compromised by immuno-suppression through malnutrition, infection and other stressors. This may reduce the proportion of dogs that seroconvert to the vaccine during vaccination campaigns and the duration of immunity of those dogs that seroconvert. Vaccination coverage may also be limited through insufficient vaccine delivery during vaccination campaigns and the loss of vaccinated individuals from populations throu

SUBMITTER: Morters MK 

PROVIDER: S-EPMC4230884 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature