Phylogenetically driven sequencing of extremely halophilic archaea reveals strategies for static and dynamic osmo-response.

ABSTRACT: Organisms across the tree of life use a variety of mechanisms to respond to stress-inducing fluctuations in osmotic conditions. Cellular response mechanisms and phenotypes associated with osmoadaptation also play important roles in bacterial virulence, human health, agricultural production and many other biological systems. To improve understanding of osmoadaptive strategies, we have generated 59 high-quality draft genomes for the haloarchaea (a euryarchaeal clade whose members thrive in hypersaline environments and routinely experience drastic changes in environmental salinity) and analyzed these new genomes in combination with those from 21 previously sequenced haloarchaeal isolates. We propose a generalized model for haloarchaeal management of cytoplasmic osmolarity in response to osmot

SUBMITTER: Becker EA 

PROVIDER: S-EPMC4230888 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature