Baseline characteristics predict risk of progression and response to combined medical therapy for benign prostatic hyperplasia (BPH).

ABSTRACT:

Objective

To better risk stratify patients, using baseline characteristics, to help optimise decision-making for men with moderate-to-severe lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) through a secondary analysis of the Medical Therapy of Prostatic Symptoms (MTOPS) trial.

Patients and methods

After review of the literature, we identified potential baseline risk factors for BPH progression. Using bivariate tests in a secondary analysis of MTOPS data, we determined which variables retained prognostic significance. We then used these factors in Cox proportional hazard modelling to: i) more comprehensively risk stratify the study population based on pre-treatment parameters and ii) to determine which risk strata stood to benefit most from

SUBMITTER: Kozminski MA 

PROVIDER: S-EPMC4231026 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature