Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview.

ABSTRACT: This article provides an introductory overview of the investigative strategy employed to evaluate the genetic basis of 17 endophenotypes examined as part of a 20-year data collection effort from the Minnesota Center for Twin and Family Research. Included are characterization of the study samples, descriptive statistics for key properties of the psychophysiological measures, and rationale behind the steps taken in the molecular genetic study design. The statistical approach included (a) biometric analysis of twin and family data, (b) heritability analysis using 527,829 single nucleotide polymorphisms (SNPs), (c) genome-wide association analysis of these SNPs and 17,601 autosomal genes, (d) follow-up analyses of candidate SNPs and genes hypothesized to have an association with each endopheno

SUBMITTER: Iacono WG 

PROVIDER: S-EPMC4231489 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature