Genome evolution and plasticity of Serratia marcescens, an important multidrug-resistant nosocomial pathogen.

ABSTRACT: Serratia marcescens is an important nosocomial pathogen that can cause an array of infections, most notably of the urinary tract and bloodstream. Naturally, it is found in many environmental niches, and is capable of infecting plants and animals. The emergence and spread of multidrug-resistant strains producing extended-spectrum or metallo beta-lactamases now pose a threat to public health worldwide. Here we report the complete genome sequences of two carefully selected S. marcescens strains, a multidrug-resistant clinical isolate (strain SM39) and an insect isolate (strain Db11). Our comparative analyses reveal the core genome of S. marcescens and define the potential metabolic capacity, virulence, and multidrug resistance of this species. We show a remarkable intraspecies genetic diversi

SUBMITTER: Iguchi A 

PROVIDER: S-EPMC4231636 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature