Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.

ABSTRACT:

Background

Poor vitamin K status is linked to greater risk of several chronic diseases. Age, sex, and diet are determinants of circulating vitamin K; however, there is still large unexplained interindividual variability in vitamin K status. Although a strong genetic component has been hypothesized, this has yet to be examined by a genome-wide association (GWA) study.

Objective

The objective was to identify common genetic variants associated with concentrations of circulating phylloquinone, the primary circulating form of vitamin K.

Design

We conducted a 2-stage GWA meta-analysis of circulating phylloquinone in 2 populations of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium Nutrition Working Group. Circulating phylloqu

SUBMITTER: Dashti HS 

PROVIDER: S-EPMC4232014 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature