The burden of invasive pneumococcal disease in children with underlying risk factors in North America and Europe.

ABSTRACT:

Background

Characterisation of risk groups who may benefit from pneumococcal vaccination is essential for the generation of recommendations and policy.

Methods

We reviewed the literature to provide information on the incidence and risk of invasive pneumococcal disease (IPD) in at-risk children in Europe and North America. The PubMed database was searched using predefined search terms and inclusion/exclusion criteria for papers reporting European or North American data on the incidence or risk of IPD in children with underlying medical conditions.

Results

Eighteen references were identified, 11 from North America and 7 from Europe, with heterogeneous study methods, periods and populations. The highest incidence was seen in US children positive for human immunodeficienc

SUBMITTER: Rose MA 

PROVIDER: S-EPMC4232238 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature