Peripheral CD4+ T cell cytokine responses following human challenge and re-challenge with Campylobacter jejuni.

ABSTRACT: Campylobacter jejuni is a leading cause of human gastroenteritis worldwide; however, our understanding of the human immune response to C. jejuni infection is limited. A previous human challenge model has shown that C. jejuni elicits IFNγ production by peripheral blood mononuclear cells, a response associated with protection from clinical disease following re-infection. In this study, we investigate T lymphocyte profiles associated with campylobacteriosis using specimens from a new human challenge model in which C. jejuni-naïve subjects were challenged and re-challenged with C. jejuni CG8421. Multiparameter flow cytometry was used to investigate T lymphocytes as a source of cytokines, including IFNγ, and to identify cytokine patterns associated with either campylobacteriosis or protection f

SUBMITTER: Fimlaid KA 

PROVIDER: S-EPMC4232357 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature