Association between MC4R rs17782313 polymorphism and overeating behaviors.

ABSTRACT:

Background/objectives

Melanocortins have a crucial role in appetite and weight regulation. Although the melanocortin 4 receptor (MC4R) gene has been repeatedly linked to obesity and antipsychotic-induced weight gain, the mechanism behind how it leads to this effect in still undetermined. The goal of this study was to conduct an in-depth and sophisticated analysis of MC4R polymorphisms, body mass index (BMI), eating behavior and depressed mood.

Subjects/methods

We genotyped 328 individuals of European ancestry on the following MC4R markers based on the relevant literature on obesity and antipsychotic-induced weight gain: rs571312, rs17782313, rs489693, rs11872992, and rs8087522. Height and weight were measured, and information on depressed mood and overeating behaviors was ob

SUBMITTER: Yilmaz Z 

PROVIDER: S-EPMC4232480 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature