Investigation of variants in UCP2 in Chinese type 2 diabetes and diabetic retinopathy.

ABSTRACT:

Purpose

The aim of this study was to investigate variants in UCP2 genes in type 2 diabetes mellitus (DM) and diabetic retinopathy (DR) in Chinese population.

Materials and methods

We conducted a single nucleotide polymorphism-based and haplotype-based case-control study between the variants of UCP2 and DM and between the variants of UCP2 and DR in 479 Chinese patients with type 2 DM and 479 control subjects without DM. Two SNPs (rs660339 and rs659366) were selected as genetic markers.

Results

The risk allele C at UCP2 rs660339 was closely associated with DM in Chinese population. There was significant difference in rs660339 between DM and controls (P = 0.0016; OR [95%CI]  = 1.37 (1.14-1.65)). Subjects who were homozygous of the C allele were more likely to develop DM.

SUBMITTER: Shen Y 

PROVIDER: S-EPMC4232517 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature