Pdsg1 and Pdsg2, novel proteins involved in developmental genome remodelling in Paramecium.

ABSTRACT: The epigenetic influence of maternal cells on the development of their progeny has long been studied in various eukaryotes. Multicellular organisms usually provide their zygotes not only with nutrients but also with functional elements required for proper development, such as coding and non-coding RNAs. These maternally deposited RNAs exhibit a variety of functions, from regulating gene expression to assuring genome integrity. In ciliates, such as Paramecium these RNAs participate in the programming of large-scale genome reorganization during development, distinguishing germline-limited DNA, which is excised, from somatic-destined DNA. Only a handful of proteins playing roles in this process have been identified so far, including typical RNAi-derived factors such as Dicer-like and Piwi pro

SUBMITTER: Arambasic M 

PROVIDER: S-EPMC4232520 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature