MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis.

ABSTRACT:

Background

MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The present meta-analysis summarises and analyses the associations between miR-21 status and overall survival (OS) in a variety of tumours.

Methods

Eligible published studies were identified by searching the PubMed and Chinese Biomedicine databases. The patients' clinical characteristics and survival results were pooled, and a pooled hazard ratio (HR) with 95% confidence intervals (95% CI) was used to calculate the strength of this association. A random-effects mode

SUBMITTER: Wang W 

PROVIDER: S-EPMC4232634 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature