The C. elegans dosage compensation complex mediates interphase X chromosome compaction.

ABSTRACT:

Background

Dosage compensation is a specialized gene regulatory mechanism which equalizes X-linked gene expression between sexes. In Caenorhabditis elegans, dosage compensation is achieved by the activity of the dosage compensation complex (DCC). The DCC localizes to both X chromosomes in hermaphrodites to downregulate gene expression by half. The DCC contains a subcomplex (condensin I(DC)) similar to the evolutionarily conserved condensin complexes which play fundamental roles in chromosome dynamics during mitosis and meiosis. Therefore, mechanisms related to mitotic chromosome condensation have been long hypothesized to mediate dosage compensation. However experimental evidence was lacking.

Results

Using 3D FISH microscopy to measure the volumes of X and chromosome I terri

SUBMITTER: Lau AC 

PROVIDER: S-EPMC4232692 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature