Prophylactic cranial irradiation for patients with small-cell lung cancer: a systematic review of the literature with meta-analysis.

ABSTRACT:

Background

Small cell lung cancer (SCLC) accounts for about 13% of all lung cancer cases. Small cell lung cancer (SCLC) accounts for about 13% of all lung cancer cases. The purpose of the present article is to assess the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) by performing a systematic review of the randomized trials published in the literature.

Methods

Randomized controlled trials were identified that compared brain metastases incidence and overall survival between PCI and No PCI in patients with SCLC. Search strategies were limited to the English language and to articles published since 1997, and included: databases searched from 1997 to March 2013 -CINAHL, Embase, Medline, Web of Science, and CENTRAL. Methodological quality was ass

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4232715 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature