Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection.

ABSTRACT:

Background

Lassa virus and Marburg virus are two causative agents of viral hemorrhagic fever. Their diagnosis is difficult because patients infected with either pathogen present similar nonspecific symptoms early after infection. Current diagnostic tests are based on detecting viral proteins or nucleic acids in the blood, but these cannot be found during the early stages of disease, before the virus starts replicating in the blood. Using the transcriptional response of the host during infection can lead to earlier diagnoses compared to those of traditional methods.

Results

In this study, we use RNA sequencing to obtain a high-resolution view of the in vivo transcriptional dynamics of peripheral blood mononuclear cells (PBMCs) throughout both types of infection. We report a s

SUBMITTER: Caballero IS 

PROVIDER: S-EPMC4232721 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature