Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.

ABSTRACT: TALE (three amino acids loop extension) homeodomain transcription factors are required in various steps of embryo development, in many adult physiological functions, and are involved in important pathologies. This review focuses on the PREP, MEIS, and PBX sub-families of TALE factors and aims at giving information on their biochemical properties, i.e., structure, interactors, and interaction surfaces. Members of the three sets of protein form dimers in which the common partner is PBX but they can also directly interact with other proteins forming higher-order complexes, in particular HOX. Finally, recent advances in determining the genome-wide DNA-binding sites of PREP1, MEIS1, and PBX1, and their partial correspondence with the binding sites of some HOX proteins, are reviewed. These studi

SUBMITTER: Longobardi E 

PROVIDER: S-EPMC4232920 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature