Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle.

ABSTRACT:

Background

The objective of the current study was to determine changes to vascular parameters of nonhuman primate dominant ovarian structures by dynamic contrast-enhanced ultrasound (DCE-US).

Materials and methods

Dynamic contrast-enhanced ultrasound with intravenous microbubble infusion was performed on the rhesus macaque ovary bearing the pre-ovulatory follicle and corpus luteum (CL) sequentially during the natural luteal phase (n = 8) and GnRH antagonist (antide)-induced luteal regression (n = 6).

Results

Changes in luteal blood volume (BV) and vascular flow (VF) were observed between stages of the luteal phase Luteal BV was highest in early stage CL, before decreasing 2.5-fold in late stage CL (P < 0.06); in contrast, luteal VF peaked at mid luteal stage (P < 0.01

SUBMITTER: Bishop CV 

PROVIDER: S-EPMC4232987 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature