Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties.

ABSTRACT:

Background

Individuals with major depressive disorder (MDD) are characterized by maladaptive responses to both positive and negative outcomes, which have been linked to localized abnormal activations in cortical and striatal brain regions. However, the exact neural circuitry implicated in such abnormalities remains largely unexplored.

Method

In this study 26 unmedicated adults with MDD and 29 matched healthy controls (HCs) completed a monetary incentive delay task during functional magnetic resonance imaging (fMRI). Psychophysiological interaction (PPI) analyses probed group differences in connectivity separately in response to positive and negative outcomes (i.e. monetary gains and penalties).

Results

Relative to HCs, MDD subjects displayed decreased connectivity bet

SUBMITTER: Admon R 

PROVIDER: S-EPMC4233014 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature